Originally Posted by ID Saraibre Ryu
You hold a Flame Orb or Toxic Orb on your Pokemon, use Protect first turn, then viola, you get Burned or Poisoned.
Protect is a waste of a move for orb activation, just switch in on something you aren't gonna be hurt by and it will activate on the same turn. Flame orb should only be used alongside guts, or its effects will cancel out the boost.
EDIT: Switching in on a single layer of toxic spikes works nicely, its damage is minimal and it absorbs the layer for following pokes.