After registering both forms of Kyurem in the pokedex, something jumped out as interesting when checking an older Pokedex from Kanto.
This is Mewtwos Leafgreen Pokedex Entry :
Mewtwo # 150
6'07" 269.0 lbs
It was created by a scientist after years of horrific gene-splicing and DNA-engineering experiments.
So DNA Splicing has been around since the first Pokemon Movie, This is a really old Pokedex Entry from my Gotta catch 'em all Pokedex,
Thought it was interesting.